abstract：:Patients with chronic pain often report being sensitive to pain at night before falling asleep, a time when the synchronization of cortical activity is initiated. However, how cortical activity relates to pain sensitivity is still unclear. Because sleep is characterized by enhanced cortical delta power, we hypothesize...

journal_title：Pain

authors： Li YD,Ge J,Luo YJ,Xu W,Wang J,Lazarus M,Hong ZY,Qu WM,Huang ZL

更新日期：2020-02-01 00:00:00

abstract：:The objective of this study was to examine pain as a predictor of frailty over 18 years of follow-up among older Mexican Americans who were nonfrail at baseline. Data were from a prospective cohort study of 1545 community-dwelling Mexican Americans aged ≥67 years from the Hispanic Established Populations for the Epide...

journal_title：Pain

authors： Sodhi JK,Karmarkar A,Raji M,Markides KS,Ottenbacher KJ,Al Snih S

更新日期：2020-01-01 00:00:00

abstract：:The investigation of neurotransmitter systems in placebo and nocebo effects has improved our understanding of these phenomena. Yet, most studies involve healthy participants. Because the pain modulatory system may differ in healthy participants and patients with chronic pain, it is important to investigate the evidenc...

journal_title：Pain

authors： Skyt I,Lunde SJ,Baastrup C,Svensson P,Jensen TS,Vase L

更新日期：2020-01-01 00:00:00

abstract：:Opioid use for chronic pain is limited by severe central adverse effects. We examined whether activating mu-opioid receptors (MORs) in the peripheral nervous system attenuates spinal cord injury (SCI) pain-like behavior in mice. We produced a contusive SCI at the T10 vertebral level and examined motor and sensory dysf...

journal_title：Pain

authors： Liu S,Huang Q,He S,Chen Z,Gao X,Ma D,Duan W,Ford N,Yang F,Chen X,Raja SN,Hao D,Guan Y

更新日期：2019-12-01 00:00:00

abstract：:Migraine headache is an episodic phenomenon, and patients with episodic migraine have ictal (headache), peri-ictal (premonitory, aura, and postdrome), and interictal (asymptomatic) phases. We aimed to find the functional characteristics of the migraine brain regardless of headache phase using dynamic functional connec...

journal_title：Pain

authors： Lee MJ,Park BY,Cho S,Park H,Kim ST,Chung CS

更新日期：2019-12-01 00:00:00

abstract：:There is evidence of greater opioid prescription to individuals in the United States with mental health conditions. Whether these associations generalize beyond the US prescription environment and to familial mental health and socioeconomic status (SES) has not been examined comprehensively. This study estimated assoc...

journal_title：Pain

authors： Quinn PD,Rickert ME,Franck J,Sariaslan A,Boersma K,Lichtenstein P,Larsson H,D'Onofrio BM

更新日期：2019-11-01 00:00:00

abstract：:Fibromyalgia (FM) syndrome represents a great challenge for clinicians and researchers because the efficacy of currently available treatments is limited. This study examined the efficacy of mindfulness-based stress reduction (MBSR) for reducing functional impairment as well as the role of mindfulness-related construct...

journal_title：Pain

authors： Pérez-Aranda A,Feliu-Soler A,Montero-Marín J,García-Campayo J,Andrés-Rodríguez L,Borràs X,Rozadilla-Sacanell A,Peñarrubia-Maria MT,Angarita-Osorio N,McCracken LM,Luciano JV

更新日期：2019-11-01 00:00:00

abstract：:Endometriosis, an estrogen-dependent chronic inflammatory disease, is the most common cause of chronic pelvic pain. Here, we investigated the effects of linaclotide, a Food and Drug Administration-approved treatment for IBS-C, in a rat model of endometriosis. Eight weeks after endometrium transplantation into the inte...

journal_title：Pain

authors： Ge P,Ren J,Harrington AM,Grundy L,Castro J,Brierley SM,Hannig G

更新日期：2019-11-01 00:00:00

abstract：:Children of parents with chronic pain have higher rates of pain and internalizing (eg, anxiety and depressive) symptoms than children of parents without chronic pain. Parental modeling of pain behaviour and reinforcement of child pain have been hypothesized to underlie these relationships. These mechanisms were tested...

journal_title：Pain

authors： Higgins KS,Chambers CT,Rosen NO,Sherry S,Mohammadi S,Lynch M,Campbell-Yeo M,Clark AJ

更新日期：2019-11-01 00:00:00

abstract：:Neuropathic pain can be a predictor of severe emotional distress, up to full-blown depressive states. In these patients, it is important to move beyond the sole treatment of pain, to recognize depressive symptoms, and to ultimately improve the quality of life. We systematically searched for published and unpublished c...

journal_title：Pain

authors： Caruso R,Ostuzzi G,Turrini G,Ballette F,Recla E,Dall'Olio R,Croce E,Casoni B,Grassi L,Barbui C

更新日期：2019-10-01 00:00:00

abstract：:Human and animal imaging studies demonstrated that chronic pain profoundly alters the structure and the functionality of several brain regions. In this article, we conducted a longitudinal and multimodal study to assess how chronic pain affects the brain. Using the spared nerve injury model which promotes both long-la...

journal_title：Pain

authors： Barrière DA,Hamieh AM,Magalhães R,Traoré A,Barbier J,Bonny JM,Ardid D,Busserolles J,Mériaux S,Marchand F

更新日期：2019-10-01 00:00:00

abstract：:Mounting evidence suggests that the spinal dorsal horn (SDH) contains multiple subpopulations of inhibitory interneurons that play distinct roles in somatosensory processing, as exemplified by the importance of spinal dynorphin-expressing neurons for the suppression of mechanical pain and chemical itch. Although it is...

journal_title：Pain

authors： Serafin EK,Chamessian A,Li J,Zhang X,McGann A,Brewer CL,Berta T,Baccei M

更新日期：2019-10-01 00:00:00

abstract：:The spinal gray matter region around the central canal, lamina X, is critically involved in somatosensory processing and visceral nociception. Although several classes of primary afferent fibers terminate or decussate in this area, little is known about organization and functional significance of the afferent supply o...

journal_title：Pain

authors： Krotov V,Tokhtamysh A,Safronov BV,Belan P,Voitenko N

更新日期：2019-09-01 00:00:00

abstract：:We know little about the safety or efficacy of pharmacological medicines for children and adolescents with chronic pain, despite their common use. Our aim was to conduct an overview review of systematic reviews of pharmacological interventions that purport to reduce pain in children with chronic noncancer pain (CNCP) ...

journal_title：Pain

authors： Eccleston C,Fisher E,Cooper TE,Grégoire MC,Heathcote LC,Krane E,Lord SM,Sethna NF,Anderson AK,Anderson B,Clinch J,Gray AL,Gold JI,Howard RF,Ljungman G,Moore RA,Schechter N,Wiffen PJ,Wilkinson NMR,Williams DG,Wood

更新日期：2019-08-01 00:00:00

abstract：:Genetics studies on the placebo hypoalgesic effect highlight a promising link between single nucleotide polymorphisms (SNPs) in the dopamine, opioid, and endocannabinoid genes and placebo hypoalgesia. However, epistasis and replication studies are missing. In this study, we expanded on previous findings related to the...

journal_title：Pain

authors： Colloca L,Wang Y,Martinez PE,Chang YC,Ryan KA,Hodgkinson C,Goldman D,Dorsey SG

更新日期：2019-08-01 00:00:00

abstract：:Migraine encompasses a broader spectrum of sensory symptoms than just headache. These "other" symptoms, eg, sensory phobias, cognitive and mood changes, allodynia, and many others indicate an altered sensitivity to sensory input which can be measured, in principle, by quantifying sensory threshold changes longitudinal...

journal_title：Pain

authors： Peng KP,May A

更新日期：2019-07-01 00:00:00

abstract：:Multimodal neuroimaging studies provide support for a role of alterations in sensory processing circuits and endogenous pain modulatory systems in provoked vestibulodynia (PVD). In this study, we tested the hypotheses that PVD compared with healthy controls (HCs) would demonstrate gray matter volume (GMV) alterations ...

journal_title：Pain

authors： Bhatt RR,Gupta A,Rapkin A,Kilpatrick LA,Hamadani K,Pazmany E,Van Oudenhove L,Stains J,Aerts L,Enzlin P,Tillisch K,Mayer EA,Labus JS

更新日期：2019-07-01 00:00:00

abstract：:Posttraumatic injury pain is commonly treated with oral nonsteroidal anti-inflammatory drugs. However, oral nonsteroidal anti-inflammatory drugs cause several adverse events, with topical formulations arising as an important alternative. Therefore, we aimed at evaluating the efficacy and safety of loxoprofen patch (LX...

journal_title：Pain

authors： Fujiki EN,Netto NA,Kraychete DC,Daher MT,Tardini R,Nakamoto A,Lopes DG

更新日期：2019-07-01 00:00:00

abstract：:The chronic pain syndrome inherited erythromelalgia (IEM) is attributed to mutations in the voltage-gated sodium channel (NaV) 1.7. Still, recent studies targeting NaV1.7 in clinical trials have provided conflicting results. Here, we differentiated induced pluripotent stem cells from IEM patients with the NaV1.7/I848T...

journal_title：Pain

authors： Meents JE,Bressan E,Sontag S,Foerster A,Hautvast P,Rösseler C,Hampl M,Schüler H,Goetzke R,Le TKC,Kleggetveit IP,Le Cann K,Kerth C,Rush AM,Rogers M,Kohl Z,Schmelz M,Wagner W,Jørum E,Namer B,Winner B,Zenke M,Lam

更新日期：2019-06-01 00:00:00

abstract：:Mechanical allodynia is pain caused by normally innocuous mechanical stimuli and is a cardinal and intractable symptom of neuropathic pain. Roles of low-threshold mechanoreceptors (LTMRs), including Aβ fibers, in mechanical allodynia have previously been proposed, but the necessity and sufficiency of LTMRs in allodyni...

journal_title：Pain

authors： Tsuda M

更新日期：2019-05-01 00:00:00

abstract：:Pain-related diseases are the top leading causes of life disability. Identifying brain regions involved in persistent neuronal changes will provide new insights for developing efficient chronic pain treatment. Here, we showed that anterior nucleus of paraventricular thalamus (PVA) plays an essential role in the develo...

journal_title：Pain

authors： Chang YT,Chen WH,Shih HC,Min MY,Shyu BC,Chen CC

更新日期：2019-05-01 00:00:00

abstract：:Multiple sclerosis (MS) is a neurodegenerative autoimmune disease with many known structural and functional changes in the central nervous system. A well-recognized, but poorly understood, complication of MS is chronic pain. Little is known regarding the influence of sex on the development and maintenance of MS-relate...

journal_title：Pain

authors： Catuneanu A,Paylor JW,Winship I,Colbourne F,Kerr BJ

更新日期：2019-05-01 00:00:00

abstract：:Chronic pain due to surgery, radiotherapy, or chemotherapy is prevalent in long-term cancer survivors. Chronic pain due to successful cancer treatment should be treated as chronic nonmalignant pain, primarily with nonpharmacological strategies. Based on complete national data from the Cancer Registry of Norway and the...

journal_title：Pain

authors： Fredheim OM,Skurtveit S,Handal M,Hjellvik V

更新日期：2019-04-01 00:00:00

abstract：:A large body of evidence indicates that nitric oxide (NO)/cGMP signaling essentially contributes to the processing of chronic pain. In general, NO-induced cGMP formation is catalyzed by 2 isoforms of guanylyl cyclase, NO-sensitive guanylyl cyclase 1 (NO-GC1) and 2 (NO-GC2). However, the specific functions of the 2 iso...

journal_title：Pain

authors： Petersen J,Mergia E,Kennel L,Drees O,Steubing RD,Real CI,Kallenborn-Gerhardt W,Lu R,Friebe A,Koesling D,Schmidtko A

更新日期：2019-03-01 00:00:00

abstract：:The processing of pain in the central nervous system is now known to have an important immune component, including T cells of the adaptive immune system. T cells have been shown to release endogenous opioids, and although it is well known that opioids have effects on T-cell populations, very little attention has been ...

journal_title：Pain

authors： Rosen SF,Ham B,Haichin M,Walters IC,Tohyama S,Sotocinal SG,Mogil JS

更新日期：2019-02-01 00:00:00

abstract：:Studies have shown that moderate alcohol consumption is strongly associated with reduced reporting of chronic widespread pain (CWP). The study designs used, however, are prone to confounding and are not able to establish the direction of causality. The current study overcomes these problems using the Mendelian randomi...

journal_title：Pain

authors： Beasley M,Freidin MB,Basu N,Williams FMK,Macfarlane GJ

更新日期：2019-02-01 00:00:00

abstract：:Chronic pain after tissue trauma is frequent and may have a lasting impact on the functioning and quality of life of the affected person. Despite this, chronic postsurgical and posttraumatic pain is underrecognised and, consequently, undertreated. It is not represented in the current International Classification of Di...

journal_title：Pain

authors： Schug SA,Lavand'homme P,Barke A,Korwisi B,Rief W,Treede RD,IASP Taskforce for the Classification of Chronic Pain.

更新日期：2019-01-01 00:00:00

abstract：:Catechol-O-methyltransferase (COMT) regulates extracellular catecholamines. A widely studied COMT single nucleotide polymorphism (rs4680) changes the translated amino acid from valine to methionine (Val158Met); the polymorphism has been shown to influence opioid use. The aims of this study were to investigate the infl...

journal_title：Pain

authors： Hooten WM,Biernacka JM,O'Brien TG,Cunningham JM,Black JL

更新日期：2019-01-01 00:00:00

abstract：:The left dorsolateral prefrontal cortex (DLPFC) is involved in the experience and modulation of pain, and may be an important node linking pain and cognition. Repetitive transcranial magnetic stimulation (rTMS) to the left DLPFC can reduce chronic and experimental pain. However, whether left DLPFC rTMS can influence t...

journal_title：Pain

authors： Seminowicz DA,de Martino E,Schabrun SM,Graven-Nielsen T

更新日期：2018-12-01 00:00:00

abstract：:To address the lack of appropriate patient-defined quality indicators (QIs) for assessment of pain clinic care in the Netherlands, we developed the "Quality Indicators Pain Patients' Perspective" (QiPPP) questionnaire. Quality indicators are widely used to measure the quality of the structure, process, and outcome of ...

journal_title：Pain

authors： de Meij N,Köke A,Thomassen I,Kallewaard JW,van Kleef M,van der Weijden T

更新日期：2018-12-01 00:00:00

abstract：:Changes in brain function in chronic pain have been studied using paradigms that deliver acute pain-eliciting stimuli or assess the brain at rest. Although motor disability accompanies many chronic pain conditions, few studies have directly assessed brain activity during motor function in individuals with chronic pain...

journal_title：Pain

authors： Roy A,Wang WE,Ho RLM,Ribeiro-Dasilva MC,Fillingim RB,Coombes SA

更新日期：2018-12-01 00:00:00

abstract：:Pediatric chronic pain is associated with numerous negative outcomes including increased physical disability, increased rates of depression and anxiety, and decreased quality of life (QOL). Pain catastrophizing-broadly conceptualized as including rumination, magnification, and helplessness cognitions surrounding one's...

journal_title：Pain

authors： Miller MM,Meints SM,Hirsh AT

更新日期：2018-12-01 00:00:00

abstract：:Oxytocin (OT), known for its neurohormonal effects around birth, has recently been suggested for being a critical determinant in neurodevelopmental disorders. This hypothalamic neuropeptide exerts a potent analgesic effect through an action on the nociceptive system. This endogenous control of pain has an important ad...

journal_title：Pain

authors： Melchior M,Juif PE,Gazzo G,Petit-Demoulière N,Chavant V,Lacaud A,Goumon Y,Charlet A,Lelièvre V,Poisbeau P

更新日期：2018-12-01 00:00:00

abstract：:Network meta-analysis uses direct comparisons of interventions within randomized controlled trials and indirect comparisons across them. Network meta-analysis uses more data than a series of direct comparisons with placebo, and theoretically should produce more reliable results. We used a Cochrane overview review of a...

journal_title：Pain

authors： Moore RA,Derry S,Wiffen PJ,Banerjee S,Karan R,Glimm E,Wiksten A,Aldington D,Eccleston C

更新日期：2018-11-01 00:00:00

abstract：:Anti-nerve growth factor (anti-NGF) therapy has shown significant promise in attenuating several types of skeletal pain. However, whether anti-NGF therapy changes the level of physical activity in individuals with or without skeletal pain is largely unknown. Here, automated day/night activity boxes monitored the effec...

journal_title：Pain

authors： Majuta LA,Mitchell SAT,Kuskowski MA,Mantyh PW

更新日期：2018-11-01 00:00:00

abstract：:Movement is changed in pain, but the mechanisms remain unclear. Key questions are unresolved such as whether activation can be inhomogeneously distributed within a muscle in a manner that is specific to the location of noxious input. This study addressed this question using high-density electromyography (EMG) to study...

journal_title：Pain

authors： Gallina A,Salomoni SE,Hall LM,Tucker K,Garland SJ,Hodges PW

更新日期：2018-11-01 00:00:00

abstract：:Capture-recapture methods are increasingly used to determine the prevalence of numerous chronic conditions but have never been used in the context of chronic pain (CP). This study sought to provide up-to-date estimates of the prevalence of people experiencing CP ± neuropathic characteristics in France using the captur...

journal_title：Pain

authors： Chenaf C,Delorme J,Delage N,Ardid D,Eschalier A,Authier N

更新日期：2018-11-01 00:00:00

abstract：:We describe qualitative and quantitative development and preliminary validation of the Patient Assessment for Low Back Pain-Impacts (PAL-I), a patient-reported outcome measure for use in chronic low back pain (cLBP) clinical trials. Concept elicitation and cognitive interviews (qualitative methods) were used to identi...

journal_title：Pain

authors： Bushnell DM,Blum SI,Liedgens H,Martin ML,Freynhagen R,Wallace M,Argoff C,Eerdekens M,Kok M,Patrick DL

更新日期：2018-10-01 00:00:00

abstract：:The TRPA1 and TRPV1 receptors are important pharmaceutical targets for antipruritic and analgesic therapy. Obtaining further knowledge on their roles and interrelationship in humans is therefore crucial. Preclinical results are contradictory concerning coexpression and functional interdependency of TRPV1 and TRPA1, bu...

journal_title：Pain

authors： Nielsen TA,Eriksen MA,Gazerani P,Andersen HH

更新日期：2018-10-01 00:00:00

abstract：:Musculoskeletal trauma and pain can sensitize central pain mechanisms, but whether these normalize on recovery is unknown. This study compared the extent of pain referral in individuals recovered from a musculoskeletal trauma and healthy controls. Twenty pain-free participants recovered from a shoulder fracture and 20...

journal_title：Pain

authors： Doménech-García V,Skuli Palsson T,Boudreau SA,Herrero P,Graven-Nielsen T

更新日期：2018-10-01 00:00:00